SGC3027 is a histone methyltransferase inhibitor, described as the first potent, selective, and cell-active chemical probe for PRMT7. It functions as a prodrug of SGC8158, becoming active upon cellular reduction by reductases. In C2C12 cellular assays, SGC3027 inhibits the methylation of HSP70 with an IC50 of 1.3 μM.
- Potent, selective, and cell-active chemical probe for PRMT7
- Prodrug that releases its active component (SGC8158) upon cellular reduction